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. 2021 Jan 15;11:1529. doi: 10.1038/s41598-020-80325-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) The position of missense variants on the 3D structure of ACE2 receptor. The residues of 26 and 331 located at the ACE2 binding site to viral Spike protein, the residue 373 is in the vicinity of the zinc ion binding residues, and residues of 708 and 650 are in the binding site of the ACE2 to TMPRSS2. This figure has been produced by the UCSF Chimera 1.14-linux_x86_64 (https://www.cgl.ucsf.edu/chimera/download.html). (b) Missense ACE2 variants in Iran, China, and 1000 Genome Project populations.