Table 2.

Docking analysis of the wild-type and mutated ACE2 structure with the Spike monomer protein.

	Haddock score	Clustered structures	Cluster size	z-score	Number of Hydrogen bonding
Spike-ACE2 (wild type)	− 136.0 ± 6.1	167	115	− 2.2	14
Spike-ACE2(LYZ26>ARG)	− 127.8 ± 2.8	153	95	− 1.8	11
Spike -ACE2(SER331>PHE)	− 122.5 ± 1.8	165	96	− 1.9	8

The column of “Haddock score” in this table shows the score of the best-obtained complex, the column “Clustered structures” is the number of complexes that finally clustered by the haddock server (we set the initial docking number = 2000 and the number of structure for final analyses = 200) and Cluster size represents the population size of the cluster of the best-obtained complex and the final column is the z-score of this complex among this cluster.