Table 2.
Group / Dose | Total comets scored | Males |
Females |
HCD Min-Max % Tail Intensity [95 % Range] |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Tail Intensity |
Tail Moment |
Hedgehogs (%) | Tail Intensity |
Tail Moment |
Hedgehogs (%) | |||||||
Mean | SEM | Mean | SEM | Mean | Mean | SEM | Mean | SEM | Mean | |||
Vehicle | 900 | 0.78 | 0.16 | 0.09 | 0.02 | 11.64 | 1.77 | 0.59 | 0.19 | 0.07 | 21.90 | 0.07−9.85 [0.38–5.27] |
HQ 105 mg/kg/day |
900 | 0.93 | 0.15 | 0.10 | 0.01 | 11.10 | 3.02 | 0.94 | 0.36 | 0.11 | 22.82 | |
HQ 210 mg/kg/day |
900 | 0.86 | 0.16 | 0.10 | 0.02 | 11.02 | 3.26 | 1.10 | 0.39 | 0.14 | 19.05 | |
HQ 420 mg/kg/day |
900 | 0.88 | 0.21 | 0.11 | 0.03 | 10.81 | 2.97 | 1.02 | 0.34 | 0.12 | 21.40 | |
EMS 150 mg/kg/day |
450 | 14.11** | 1.14 | 1.86 | 0.17 | 13.40 | 11.41*** | 0.37 | 1.37 | 0.08 | 26.51 | 2.58−35.10 [5.99−28.59] |
Statistics | SR, A | S, A |
SEM Standard error of the means.
** p < 0.01, *** p < 0.001.
HCD: Historical Control Data.
Statistics:
S Two-sample t-test (Vehicle vs. EMS).
SR Two-sample t-test (Vehicle vs. EMS), using rank-transformed data.
A ANOVA, Dose Response and Dunnett’s (Vehicle vs. HQ groups).