Table 3.

Comet Assay Results for the Liver of Male and Female F344 Rats Given HQ.

Group / Dose	Total comets scored	Males					Females					HCD Min-Max % Tail Intensity [95 % Range]
		Tail Intensity		Tail Moment		Hedgehogs (%)	Tail Intensity		Tail Moment		Hedgehogs (%)
		Mean	SEM	Mean	SEM	Mean	Mean	SEM	Mean	SEM	Mean
Vehicle	900	0.28	0.08	0.04	0.01	3.48	0.72	0.17	0.10	0.02	4.71	0.01−9.52 [0.05−5.06]
HQ 105 mg/kg/day	900	0.45	0.10	0.06	0.01	3.22	0.90	0.24	0.13	0.03	5.60
HQ 210 mg/kg/day	900	0.42	0.16	0.05	0.02	2.24	1.02	0.42	0.13	0.05	4.43
HQ 420 mg/kg/day	900	0.64	0.17	0.09	0.02	3.56	1.34	0.47	0.18	0.06	5.12
EMS 150 mg/kg/day	450	20.45***	2.04	3.26	0.45	5.31	21.52**	1.31	3.55	0.33	5.89	5.02−84.19 [10.65-62.51]
Statistics		DR, S, A					SR, A

SEM Standard error of the means.

**p < 0.01, *** p < 0.001.

HCD: Historical Control Data.

Statistics:

DR Significant Dose Response test (Vehicle and HQ groups).

S Two-sample t-test (Vehicle vs. EMS).

SR Two-sample t-test (Vehicle vs. EMS), using rank-transformed data.

A ANOVA, Dose Response and Dunnett’s (Vehicle vs. HQ groups).