Table 3.
Group / Dose | Total comets scored | Males |
Females |
HCD Min-Max % Tail Intensity [95 % Range] |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Tail Intensity |
Tail Moment |
Hedgehogs (%) | Tail Intensity |
Tail Moment |
Hedgehogs (%) | |||||||
Mean | SEM | Mean | SEM | Mean | Mean | SEM | Mean | SEM | Mean | |||
Vehicle | 900 | 0.28 | 0.08 | 0.04 | 0.01 | 3.48 | 0.72 | 0.17 | 0.10 | 0.02 | 4.71 | 0.01−9.52 [0.05−5.06] |
HQ 105 mg/kg/day |
900 | 0.45 | 0.10 | 0.06 | 0.01 | 3.22 | 0.90 | 0.24 | 0.13 | 0.03 | 5.60 | |
HQ 210 mg/kg/day |
900 | 0.42 | 0.16 | 0.05 | 0.02 | 2.24 | 1.02 | 0.42 | 0.13 | 0.05 | 4.43 | |
HQ 420 mg/kg/day |
900 | 0.64 | 0.17 | 0.09 | 0.02 | 3.56 | 1.34 | 0.47 | 0.18 | 0.06 | 5.12 | |
EMS 150 mg/kg/day |
450 | 20.45*** | 2.04 | 3.26 | 0.45 | 5.31 | 21.52** | 1.31 | 3.55 | 0.33 | 5.89 | 5.02−84.19 [10.65-62.51] |
Statistics | DR, S, A | SR, A |
SEM Standard error of the means.
**p < 0.01, *** p < 0.001.
HCD: Historical Control Data.
Statistics:
DR Significant Dose Response test (Vehicle and HQ groups).
S Two-sample t-test (Vehicle vs. EMS).
SR Two-sample t-test (Vehicle vs. EMS), using rank-transformed data.
A ANOVA, Dose Response and Dunnett’s (Vehicle vs. HQ groups).