Table 4.
Group / Dose | Total comets scored | Males |
Females |
HCD Min-Max % Tail Intensity [95 % Range] |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Tail Intensity |
Tail Moment |
Hedgehogs (%) | Tail Intensity |
Tail Moment |
Hedgehogs (%) | |||||||
Mean | SEM | Mean | SEM | Mean | Mean | SEM | Mean | SEM | Mean | |||
Vehicle | 900 | 1.94 | 0.46 | 0.22 | 0.05 | 11.55 | 1.02 | 0.23 | 0.12 | 0.04 | 14.50 | 0.48−6.63 [0.82−6.36] |
HQ 105 mg/kg/day |
900 | 1.49 | 0.29 | 0.18 | 0.03 | 12.10 | 1.65 | 0.74 | 0.18 | 0.08 | 17.91 | |
HQ 210 mg/kg/day |
900 | 1.38 | 0.38 | 0.17 | 0.06 | 11.00 | 0.63 | 0.22 | 0.08 | 0.03 | 17.08 | |
HQ 420 mg/kg/day |
900 | 1.67 | 0.35 | 0.19 | 0.04 | 12.59 | 0.84 | 0.27 | 0.11 | 0.03 | 17.24 | |
EMS 150 mg/kg/day |
450 | 22.18*** | 0.35 | 3.50 | 0.07 | 13.87 | 18.26** | 1.95 | 2.80 | 0.39 | 18.00 | 10.16−41.90 [NA] |
Statistics | S, A | SR, A |
SEM Standard error of the means.
**p < 0.01, *** p < 0.001.
HCD: Historical Control Data.
NA - Not applicable, insufficient datasets to calculate a relevant reference range.
Statistics:
S Two-sample t-test (Vehicle vs. EMS).
SR Two-sample t-test (Vehicle vs. EMS), using rank-transformed data.
A ANOVA, Dose Response and Dunnett’s (Vehicle vs. HQ groups).