Table 5.
Comet Assay Results for the Testes of Male F344 Rats Given HQ.
| Group / Dose | Total comets scored | Tail Intensity |
Tail Moment |
Hedgehogs (%) | HCD Min-Max % Tail Intensity [95 % Range] |
||
|---|---|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | Mean | |||
| Vehicle | 900 | 0.16 | 0.02 | 0.01 | 0.00 | 0.65 | 0.04−0.35 [NA] |
| HQ 105 mg/kg/day |
900 | 0.19 | 0.03 | 0.01 | 0.00 | 0.89 | |
| HQ 210 mg/kg/day |
900 | 0.17 | 0.02 | 0.01 | 0.00 | 0.47 | |
| HQ 420 mg/kg/day |
900 | 0.19 | 0.04 | 0.01 | 0.00 | 0.65 | |
| EMS 150 mg/kg/day |
450 | 10.71** | 0.91 | 1.09 | 0.14 | 11.86 | 12.85−15.55 [NA] |
| Statistics | SR, A | ||||||
SEM Standard error of the means.
**p < 0.01.
HCD: Historical Control Data.
NA - Not applicable, insufficient datasets to calculate a relevant reference range.
Statistics:
SR Two-sample t-test (Vehicle vs. EMS), R Rank-Transformed Data.
A ANOVA, Dose Response and Dunnett’s (Vehicle vs. HQ groups).