Table 1.

Most significant miRNAs differentially expressed between chemosensitive and chemoresistant patient groups (linear fold change > 7)

Mature miRNAs (ID)	Linear fold change resistant/sensitive	P‐value	Linear fold change based on geometric mean resistant/sensitive	AUC (ROC curve)	Random Forest feature selection frequency (%)	Validation by qRT‐PCR with a significant difference
hsa‐miR‐21‐5p (MIMAT0000076)	18.65	2.50E‐014	4.26	0.833	100	Yes
hsa‐miR‐340‐5p (MIMAT0004692)	11.79	2.59E‐011	3.6	0.846	100	No
hsa‐miR‐181c‐5p (MIMAT0000258)	7.62	7.99E‐008	3.26	0.817	100	No
hsa‐miR‐15a‐5p (MIMAT0000068)	7.21	2.15E‐011	3.22	0.886	100	Yes

The selection frequency represents the number of times a miRNA was ranked among the top 30 selected features discriminating the resistant/sensitive phenotype by the leave‐one‐out cross‐validated random forest model, using the absolute T statistics ranking.