Figure 2.

(A‐D) MaR1 reduced Aβ₄₂‐induced secretion of pro‐inflammatory cytokines in d‐THP‐1 cells. Differentiated THP‐1 (d‐THP‐1) cells were incubated with vehicle, 5 µM Aβ₄₂, 5 µmol/L MaR1 or 5 µM Aβ₄₂ + 5 µM MaR1 for 24 h and the supernatants were analysed by ELISA. A total of 14 experiments were performed. MaR1 reduced the Aβ₄₂‐induced increase in interleukin (IL)‐1β (A), tumour necrosis factor (TNF)‐α (B) and IL‐6 (C). The levels of IL‐6 receptor (R) α (D) were not affected by Aβ₄₂ nor MaR1. Analysis of variance (ANOVA) was performed with the non‐parametric Kruskal–Wallis (K‐W) test, using the built‐in post hoc test for multiple comparisons to find significant differences between treatments. ***P < 0.005 vs. vehicle. # P < 0.05, ## P < 0.01, ### P < 0.005 vs. 5 μM Aβ₄₂. Aβ = β‐amyloid; MaR1 = maresin 1