Figure 9.

MaR1 reduced Aβ₄₂‐induced NF‐κB activation. Differentiated THP‐1 (d‐THP‐1) cells were incubated with 5 µM Aβ₄₂ alone or together with 5 µM MaR1 for 24 h, after which the luminescence in the conditioned medium was measured. Incubation with vehicle served as control. Co‐incubation with MaR1 showed a significant reduction of the Aβ₄₂‐induced increase in NF‐κB activation. Analysis of variance (ANOVA) of the data was performed using the non‐parametric Kruskal–Wallis (K‐W) test. The built‐in post hoc test for multiple comparisons was used to find significant differences between treatments. *P < 0.05 vs. vehicle. #P < 0.05 vs. 5 μmol/L Aβ₄₂. Aβ = β‐amyloid; MaR1 = maresin 1