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Mutual repression between circ‐0000658 and miR‐1227. A, qRT‐PCR assay results revealed that the expression level of miR‐1227 is increased in OS tissues. B, Correlation between miR‐1227 and circ‐0000658 in OS samples. C, The binding sites between miR‐1227 and circ‐0000658, and Dual‐Luciferase reporter assay. D, RIP assay in HOS and MG63 cells. E, Circ‐0000658 inversely modulates miR‐1227 expression. Data represent the mean ± SD of 3 independent experiments; **P < 0.01, ***P < 0.001
