Table 3.
Hazard ratios and 95% confidence intervals for the incidence of composite of end-stage renal disease and all-cause mortality according to the categories of diastolic blood pressure among the individuals with chronic kidney disease.
| Categories of DBP (mmHg) | Composite of end-stage renal disease and all-cause death | |||
|---|---|---|---|---|
| Events (n) | Follow-up duration (person-years) | Incidence rate (per 1000 person-years) | Adjusted HR (95% CI)* | |
| Total | ||||
| < 60 (n = 358) | 26 | 2081 | 12.49 (8.51–18.35) | 1.401 (0.940–2.088) |
| 60–69 (n = 2964) | 141 | 17,632 | 8.00 (6.78–9.43) | 1.022 (0.840–1.243) |
| 70–79 (n = 7373) | 346 | 44,082 | 7.85 (7.06–8.72) | 1 (Ref.) |
| 80–89 (n = 8567) | 452 | 51,341 | 8.80 (8.03–9.65) | 1.150 (0.999–1.322) |
| 90–99 (n = 2230) | 184 | 13,040 | 14.11 (12.21–16.30) | 1.458 (1.218–1.746) |
| ≥ 100 (n = 786) | 76 | 4619 | 16.45 (13.14–20.60) | 1.733 (1.350–2.224) |
| P for trend | < 0.0001 | |||
| Non-users of antihypertensive agent | ||||
| < 60 (n = 214) | 6 | 1274 | 4.71 (2.12–10.48) | 1.087 (0.478–2.471) |
| 60–69 (n = 1863) | 35 | 11,306 | 3.10 (2.22–4.31) | 0.762 (0.522–1.113) |
| 70–79 (n = 4306) | 115 | 26,129 | 4.40 (3.67–5.28) | 1 (Ref.) |
| 80–89 (n = 4503) | 122 | 27,468 | 4.44 (3.72–5.30) | 1.008 (0.781–1.301) |
| 90–99 (n = 927) | 50 | 5536 | 9.03 (6.85–11.92) | 1.631 (1.169–2.275) |
| ≥ 100 (n = 361) | 17 | 2190 | 7.76 (4.83–12.49) | 1.451 (0.870–2.417) |
| P for trend | 0.0145 | |||
| Users of antihypertensive agent | ||||
| < 60 (n = 144) | 20 | 807 | 24.79 (15.99–38.43) | 1.477 (0.935–2.333) |
| 60–69 (n = 1101) | 106 | 6326 | 16.76 (13.85–20.27) | 1.141 (0.906–1.437) |
| 70–79 (n = 3067) | 231 | 17,953 | 12.87 (11.31–14.64) | 1 (Ref.) |
| 80–89 (n = 4064) | 330 | 23,873 | 13.82 (12.41–15.40) | 1.192 (1.007–1.410) |
| 90–99 (n = 1303) | 134 | 7504 | 17.86 (15.08–21.15) | 1.345 (1.087–1.665) |
| ≥ 100 (n = 425) | 59 | 2429 | 24.29 (18.82–31.35) | 1.825 (1.370–2.431) |
| P for trend | 0.0042 | |||
DBP diastolic blood pressure, HR hazard ratio, CI confidence interval.
*Adjusted for age, sex, current smoking, alcohol consumption, regular exercise, household income level, body mass index, presence of dyslipidaemia, diabetes mellitus, and urine dipstick positivity for protein. Adjusted HRs (95% CIs) and P-values, considered to be statistically significant in bold font.