Figure 3.

Contribution of inter- and intra-individual variance in longitudinal MRI data. In the longitudinal cohort of 33 patients we visualized the (A) percentage of variance explained (= adjusted r²) and (B) significance in a generic model (black) including a unique patient identifier code (i.e. inter-individual variation) and time (i.e. intra-individual variation) and a clinical model (grey) including gender, age, disease duration (i.e. known variables of inter-individual variation) and time. The dotted line represents the cut-off for significance of P ≤ 0.05 after correction for multiple testing (P ≤ 0.0025). (C) The relative contributions of inter-individual and intra-individual variation over time to the total variance explained in the generic model. PH peak height, NAWM normal appearing white matter, NAGM normal appearing grey matter, WM white matter, GM grey matter, vol volume

(Image generated with Rv3.6.1, https://www.R-project.org).