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. 2021 Jan 15;12:400. doi: 10.1038/s41467-020-20492-7

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© The Author(s) 2021

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Fig. 1 — a, b show two different methylation patterns of a promoter region that cannot be distinguished by the traditional method. c Scatter plot shows a comparison of the methylation level calculated by the traditional and CHALM methods for the promoter CGIs of CD3 primary cells.