Fig. 3. Clonal information is crucial for gene expression prediction.

a Prediction of gene expression based on raw bisulfite sequencing reads via a deep-learning framework. b Disruption of read clonal information by shuffling the mCpGs among mapped reads. c The clonal information is disrupted before prediction. Comparison of correlation (between prediction models with and without clonal information disrupted) permutation P values: <1 × 10⁻⁴.