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. 2020 Dec 29;24(1):102008. doi: 10.1016/j.isci.2020.102008

Figure 3.

Figure 3

Candida and Streptococcus mixed-biofilms on titanium surface

(A and B) Twenty-four-hour mixed biofilm stained by immuno-FISH of Candida albicans (green) and Streptococcus oralis (stained in blue on A and B and in red on C) growing on (A) titanium surface and (B) polystyrene surface. Bacterial extracellular matrix is stained with Alexa Fluor 647-labeled dextran conjugate probe (red) in figure (B). Images suggest that biofilm growth is modulated by the type of surface.

(C) C. albicans (green) and S. oralis (red) interaction on biofilm growing on the polystyrene surface.

(D) Dual species biofilms growing on the organotypic mucosal construct, which can cause epithelial barrier breach (H&E stain).

(E) Titanium-mucosal interface biofilm model. Biofilm formed on titanium surface suspended 0.5 to 1 mm above the in vitro organotypic mucosal construct surface. Reprinted (adapted) from refs (Souza et al., 2020c, Souza et al., 2020d); Copyright (2020), with permission from American Society for Microbiology and Springer Nature. Figure E created by BioRender®.