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. 2020 Dec 19;45:101149. doi: 10.1016/j.molmet.2020.101149

Figure 4.

Figure 4

The promotion effects of 7,8-DHF or BDNF on glucose consumption in C2C12 myotubes could be abolished by ERα or TrkB inhibitors. (A) Differentiated C2C12 myotubes were incubated with low, medium, and high concentrations of 7,8-DHF (0.5, 1, and 5 μmol/L, respectively), or (B) BDNF (50, 100, and 200 ng/mL, respectively) for 16 h with or without ICI182780 or k252a. Myotubes were preincubated with ICI182780 (1 μmol/L) or k252a (30 nmol/L) for 1 h (n = 6–7, ∗p < 0.05, ∗∗∗p < 0.001, N.S: not significant, one-way ANOVA).