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. 2021 Jan 15;12:14. doi: 10.1186/s13293-020-00352-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Effect of MCAo on mortality, infarct volume, and sensory-motor ability in males and females. a Kaplan-Meier survival plot shows significantly greater mortality after MCAo in males as compared to females (p = 0.0014). b Representative images of TTC-stained brain sections from female and male rats 2 days after MCAo. c Histogram depicting mean (± SEM) of infarct volume (ns, not significant). Sensory-motor impairment assessed by d adhesive removal test (ART) and e the vibrissae-evoked forelimb placement task (VIB). a Main effect of stroke. b Main effect of sex. c Interaction effect; *p < 0.05