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. 2021 Jan 15;12:14. doi: 10.1186/s13293-020-00352-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Serum levels of gut proteins/metabolites. Gut protein/metabolite levels were assayed in the serum as a surrogate measure of gut permeability. a Serum iFABP (15 kDa) was elevated after stroke in both males and females. b Serum LBP (60 kDa) shows a sex difference which was mainly due to the increased levels of the protein in male rats after MCAo compared to females. Serum levels of c LPS and d Mucin-2 were significantly elevated in males irrespective of stroke/sham group. n = 13 female MCAo, n = 5 male MCAo, n = 9 female sham, n = 6 male sham. ^aMain effect of stroke, ^bmain effect of sex, *p < 0.05