Table 3: Summary Table.

Morphological endpoints affected by, and LELs associated with, developmental exposures to e-cigarette flavors (Figure 1A) and chemical constituents (Figure 2). The left hand column lists each e-cigarette flavor or created mixture and its chemical constituents. The three right-hand columns list the most common endpoints affected, LEL values, and, where applicable, calculated EC₅₀ values. The top row is each chemical constituent and flavor it was part of, represented by an ✖. The bottom three rows in the left-hand column list the most common endpoints affected, LELs, and, where applicable, calculated EC₅₀ values. All EC₅₀ values were calculated using the mortality endpoint (MORT). ND stands for Not Determined. As in Figures 1 and 2, endpoints common to 555 and French Vanilla were also common to their chemical constituents (Ethyl Vanillin, Vanillin, and Maltol), suggesting a similar mechanism of toxicity.

Mixture/Chemical	Benzyl Alcohol	Ethyl Vanillin	Vanillin	Cinnamaldehyde	Maltol	Ethyl Butyrate	Ethyl Acetate	Endpoints	LEL (Dilution Factor)	EC50
555		✖	✖		✖			YSE, EYE, SNOUT, JAW, PE	1:1000	ND
Banana Crème Pie								YSE, Eye, SNOUT, JAW, PE	1:1000	ND
Coffee	✖							YSE	1:1000	ND
French Vanilla		✖	✖		✖			MORT, YSE, EYE, PE	1:100	ND
Cotton Candy		✖	✖					MORT	1:1000	ND
Bubble Gum				✖		✖	✖	MO24, MORT	1:1000	1 to 100
Grape						✖	✖	NA	NA	NA
Nicotine								YSE, EYE, PE	1:1000	ND
Unflavored								YSE	1:1000	ND
EA+EB						✖	✖	MO24, MORT	100 ug/mL EB	405 ug/mL
EA+EB+C				✖		✖	✖	MO24, MORT	10 ug/mL C	45.1 ug/mL
G+C				✖		✖	✖	MO24, MORT	10 ug/mL C	28.6 ug/mL
Endpoints	MORT, YSE, EYE, JAW	YSE, EYE, JAW, PE	YSE, EYE, SNOUT, JAW, PE	MORT	MO24, MORT	MO24, MORT	DP24
LEL (μg/mL)	100	10	100	0.1	1000	100	100
EC50	ND	ND	ND	11.4 ug/mL	ND	117 ug/mL	NA