Figure 2.

Effects of human immunodeficiency virus (HIV) and history of methamphetamine dependence (METH) on 5C-CPT performance across trial blocks. N = 203. Overall performance on the 5C-CPT decreased across blocks. METH+ participants exhibited poorer 5C-CPT performance relative to METH- participants, irrespective of HIV status, as measured by d prime (A). METH+ participants had significantly poorer responsivity index, compared to METH- participants, however, this was not significant following Bonferroni correction (B). Impaired responding to targets was more exaggerated as time progressed and among METH+ participants, compared to METH- participants (C). False alarm rates did not differ across blocks, or according to HIV. METH+ participants had more false alarms compared to METH- participants, however, this effect was not significant follow Bonferroni correction (D). HIV+ had lower accuracy, compared to HIV-negative people (E). The number of omissions significantly increased across trial blocks. METH+ participants had significantly elevated misses to targets (% omission; F). Reaction time slowed over trial blocks and HIV+ had significantly slower reaction time, relative to HIV- subjects (G). Finally, premature responses did not differ across blocks, or according to HIV. METH+ participants had significantly more premature responses, however, this effect was not significant following Bonferroni correction (H). Data are presented as means, with error bars representing standard error of the mean. Corresponding regression estimates, standard errors, and bootstrapped 95% confidence intervals presented in Table 4.