Table 1.
Clinical details of four patients with acute ocular involvement of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) who underwent AMT with the technique using cyanoacrylate glue
| Patient | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
| Age (years)/ Gender | 6/Female | 8/Female | 21/Female | 32/Female |
| Percentage of total BSA denuded | 30% | 30% | 10% | 25% |
| Presumed Etiology | Ibuprofen | Ibuprofen | Lamotrigine | Unknown |
| Visual acuity at presentation | RE 20/30, LE 20/25 | RE 20/20, LE 20/20 | RE 20/20, LE 20/25 | RE 20/20, LE 20/20 |
| Timing of AMT (days after onset of skin rash) | Day 4 | Day 3 | Day 4 | Day 3 |
| Ocular findings before AMT | UL desquamation of skin (BE), UL and LL margin ulceration (BE), central corneal epithelial defect (RE) | UL and LL desquamation of skin nasally (RE), BE UL and LL margin ulceration (BE), corneal epithelial defects (BE), inferior palpebral and bulbar conjunctival defects (RE) | UL margin ulceration (BE), temporal bulbar conjunctival defects (BE), palpebral conjunctival pseudomembranes (BE) | LL margin ulceration (BE), temporal bulbar conjunctival defects (BE) |
| Dissolution of AM | 6 days | 7 days | 6 days | 8 days |
| Ocular findings at last follow-up visit | irregular eyelid margin (BE), mild central LL eyelid margin keratinization (LE), tarsal conjunctival scarring (BE), meibomian gland dropout (BE) | irregular eyelid margin (BE), LL trichiasis (BE), UL and LL eyelid margin keratinization (BE), tarsal conjunctival scarring (BE), symblepharon and corneal neovascularization (RE), meibomian gland dropout | irregular eyelid margin (BE), meibomian gland disease (BE), mild LL eyelid margin keratinization (BE), tarsal conjunctival scarring (BE) | irregular eyelid margin (BE), meibomian gland disease (BE), UL and LL mild eyelid margin keratinization (BE), tarsal conjunctival scarring (BE), small symblepharon temporally (BE) |
| BCVA at last visit | RE 20/40, LE 20/40 | RE 20/80, LE 20/30 | RE 20/20, LE 20/25 | RE 20/20, LE 20/20 |
| Follow-up in months after AMT | 14 months | 15 months | 10 months | 12 months |
AM = amniotic membrane; AMT = amniotic membrane transplantation; BSA = body surface area; RE = right eye; LE = left eye; BE = both eyes; UL = upper lid; LL = lower lid; BCVA = best-corrected visual acuity