Table 1.

Basic Pharmacokinetics of First-Line Anti-Tubercular Drugs16

Drug Name	Dose	Serum Cmax (µg/mL)	Tmax (hr)	Serum T½ (hr)
Rifampicin	600mg	8–24	2	2–3
Isoniazid	300mg	3–6	0.75–2	1.5 fast 4 slow
Pyrazinamide	25–35mg/kg	20–60	1–2	9
Ethambutol	25mg/kg	2–6	2–3	Biphasic: 2–4, then 12–14