Table 1.
The 40 Differentially Expressed Autophagy-Related Genes in COPD Samples Compared to Healthy Samples
| Gene Symbol | logFC | Changes | P-value | Adj. P-value | Chromosome |
|---|---|---|---|---|---|
| NAF1 | 1.4357957 | Up | 1.56E-06 | 3.96E-05 | 4q32.2 |
| HIF1A | 1.3603498 | Up | 7.82E-06 | 0.0001444 | 14q23.2 |
| CDKN1A | 1.272822 | Up | 0.0002532 | 0.0022153 | 6p21.2 |
| BAG3 | 1.1930022 | Up | 4.63E-05 | 0.0005802 | 10q26.11 |
| CHMP4B | 1.0045764 | Up | 6.24E-12 | 2.28E-09 | 20q11.22 |
| PPP1R15A | 0.9262876 | Up | 0.0008207 | 0.0056518 | 19q13.33 |
| CFLAR | 0.9260041 | Up | 0.000208 | 0.0019141 | 2q33.1 |
| EIF2AK3 | 0.9155192 | Up | 3.94E-05 | 0.0005098 | 2p11.2 |
| CAPN10 | 0.8527256 | Up | 2.48E-08 | 1.52E-06 | 2q37.3 |
| AMBRA1 | 0.8353141 | Up | 5.43E-09 | 4.90E-07 | 11p11.2 |
| ATG4B | 0.8135798 | Up | 3.64E-09 | 3.52E-07 | 2q37.3 |
| DNAJB1 | 0.6134868 | Up | 0.0020265 | 0.0116548 | 19p13.12 |
| PTK6 | 0.608517 | Up | 0.0002323 | 0.0020772 | 20q13.33 |
| FOXO1 | 0.5948789 | Up | 0.0003144 | 0.0026293 | 13q14.11 |
| PEX3 | −0.587454 | Down | 0.0011187 | 0.0073109 | 6q24.2 |
| CAPN2 | −0.595352 | Down | 1.14E-05 | 0.0001928 | 1q41 |
| DAPK2 | −0.603068 | Down | 0.0038466 | 0.0188934 | 15q22.31 |
| CLN3 | −0.604752 | Down | 0.0088636 | 0.0357914 | 16p12.1 |
| RB1CC1 | −0.622768 | Down | 0.0002098 | 0.0019237 | 8q11.23 |
| HGS | −0.622941 | Down | 0.007054 | 0.0299605 | 17q25.3 |
| RAB24 | −0.623503 | Down | 5.40E-05 | 0.0006594 | 5q35.3 |
| NBR1 | −0.63116 | Down | 4.23E-05 | 0.0005379 | 17q21.31 |
| RAC1 | −0.632484 | Down | 8.29E-08 | 3.97E-06 | 7p22.1 |
| IKBKB | −0.652862 | Down | 3.05E-09 | 3.12E-07 | 8p11.21 |
| ULK2 | −0.666303 | Down | 0.0046861 | 0.0219625 | 17p11.2 |
| HDAC1 | −0.709992 | Down | 3.05E-10 | 5.47E-08 | 1p35.2-p35.1 |
| VEGFA | −0.719885 | Down | 0.0083788 | 0.0342328 | 6p21.1 |
| MAPK9 | −0.721893 | Down | 0.0002068 | 0.0019065 | 5q35.3 |
| PRKAR1A | −0.737878 | Down | 6.70E-05 | 0.0007753 | 17q24.2 |
| WDR45 | −0.747259 | Down | 0.0012551 | 0.008014 | Xp11.23 |
| HDAC6 | −0.761707 | Down | 3.82E-07 | 1.31E-05 | Xp11.23 |
| BNIP3 | −0.769753 | Down | 7.87E-06 | 0.0001451 | 10q26.3 |
| ITGB1 | −0.776737 | Down | 0.0004698 | 0.0036189 | 10p11.22 |
| ZFYVE1 | −0.791195 | Down | 0.0005979 | 0.0043929 | 14q24.2 |
| DAPK1 | −0.880472 | Down | 2.11E-05 | 0.0003097 | 9q21.33 |
| ITPR1 | −0.895618 | Down | 7.23E-08 | 3.55E-06 | 3p26.1 |
| ATG16L1 | −0.911281 | Down | 0.0003391 | 0.0027977 | 2q37.1 |
| FAM48A | −0.913225 | Down | 4.04E-09 | 3.85E-07 | 13q13.3 |
| GAPDH | −0.919411 | Down | 1.41E-06 | 3.66E-05 | 12p13.31 |
| ERBB2 | −0.983015 | Down | 2.12E-08 | 1.37E-06 | 17q12 |