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. 2021 Jan 12;14:41–51. doi: 10.2147/JPR.S288292

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© 2021 Ju et al.

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CXCL10 induces mechanical allodynia and increases ERK and Akt activation via CXCR3. (A and B) Intra-TG injection of CXCL10 (100 ng) induced mechanical allodynia in WT mice (A), which was reduced in Cxcr3^−/- mice (B). ** P < 0.01, *** P < 0.001, compared with PBS group or WT group. Two-way RM ANOVA followed by the Bonferroni test. (C) Intra-TG injection of CXCL10 (100 ng) increased pERK level in WT mice but not in Cxcr3^−/- mice. n=3/group. ** P < 0.01 compared with PBS group. Student’s t-test. (D, E) Intra-TG injection of CXCL10 did not affect pp38 (D) or pJNK (E) level in either WT or Cxcr3^−/- mice. n=3/group. (F) Intra-TG injection of CXCL10 induced the activation of AKT in WT mice, but not in Cxcr3^−/- mice. n=3/group. *** P < 0.001, compared with PBS group. Student’s t-test.