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. 2021 Jan 12;14:41–51. doi: 10.2147/JPR.S288292

Figure 5.

Figure 5

pIONL induces ERK and AKT activation via CXCR3. (A) pIONL-induced ERK activation was reduced in Cxcr3−/- mice than that in WT mice. * P < 0.05. Student’s t-test. (B) AKT activation was reduced in Cxcr3−/- mice than that in WT mice. * P < 0.05. Student’s t-test. (C) Intra-TG injection of AKT inhibitor IV in WT mice attenuated pIONL-induced mechanical allodynia at 1 h, 3 h, and 6 h. *** P < 0.001, compared to vehicle. Two-way RM ANOVA followed by the Bonferroni test. (D) Intra-TG injection of AKT inhibitor IV in Cxcr3−/- mice did not affect the mechanical allodynia. Two-way RM ANOVA followed by the Bonferroni test.