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. 2020 Oct 19;95(1):207–228. doi: 10.1007/s00204-020-02903-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Cell viability at DIV14 (filled circle) and 21 (open square) using resazurin reduction assay after exposure at 7DIV to FR a BDE-47, b TPHP, c IPP, d IDDP and e TMPP. All data were normalized to mean of untreated control samples (100%) and are presented as mean ± SD of at least three independent experiments performed in 2–4 replicates. Differences between treated and non-treated (control) groups were assessed by one-way ANOVA (GraphPad Prism 8.4.3), followed by Dunnett’s multiple comparison post hoc test including correction for multiple testing. Post hoc test was only performed vs. controls. Statistical significance is indicated as follow *p < 0.05 (treated vs. control). Arrows indicate concentrations selected for metabolomics and transcriptomics experiments (0.1, 1 and 5 µM)