Table 2.
Univariable analysis of potential factors related to DM at diagnosis or during follow-up
| Variable | HR (95% CI) | p value |
|---|---|---|
| Age | 0.98 (0.97–1.00) | 0.038 |
| Gender | 0.006 | |
|
Male Female |
1 0.53 (0.33–0.83) |
|
| Comorbidities | 0.895 | |
|
None Mild Moderate Severe |
1 0.93 (0.61–1.43) 0.88 (0.55–1.40) 0.82 (0.46–1.45) |
|
| Site | <0.001 | |
| Oral cavity | 1 | |
|
Larynx Oropharynx Hypopharynx |
1.15 (0.62–2.12) 2.86 (1.61–5.08) 8.28 (4.48–15.28) |
0.665 <0.001 <0.001 |
| T-stagea | <0.001 | |
| Early stage |
1 3.85 (2.70–5.48) |
|
| Advanced stage | ||
| N-stage | <0.001 | |
| N0 |
1 8.18 (5.40–12.39) |
|
| N+ | ||
| Differentiation grade | <0.001 | |
| Good (Grade I) | 1 | |
|
Moderate (Grade II) Poor (Grade III) |
2.64 (1.20–5.80) 7.73 (3.45–17.33) |
0.016 <0.001 |
| Perineural growthb | 0.400 | |
|
Yes No |
1 1.47 (0.60–3.62) |
|
| Angioinvasionb | 0.002 | |
|
No Yes |
1 3.80 (1.64–8.77) |
|
| Extranodal extensionc | 0.005 | |
|
No Yes |
1 3.10 (1.14–6.79) |
Bold numbers represent significant values (p < 0.05)
aEarly stage represents T1 and T2 tumours, advanced stage represents T3 and T4 tumours
bOnly surgically treated cases were included (n = 647)
cOnly cases with surgically treated cervical nodes were included (n = 221)