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. 2020 Dec 2;95(1):229–252. doi: 10.1007/s00204-020-02956-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Altered neuronal signaling by blocking the DAT. a Ca²⁺-imaging traces of the inhibitory effect of nomifensine on the response of LUHMES neurons to 0.3 µM AMP. b The concentration-dependent inhibition by nomifensine resulted in pIC₅₀ values of 7.55 ± 0.12 for DA and 7.71 ± 0.10 for AMP. Note the treatment scheme (lower left corner), illustrating the experimental design. Detailed data on n numbers are found in table S4