Table 3.

GEE analyses of selected blood parameters considering ZnO particle size and time of sampling

Parameter	Time of sampling	ZnO [mg/m3]	ORa	OR 95% CI	P value
Neutrophils [1/nL]	Before exposure	0	1.00
	22 after exposure	2–micro	2.11#	1.71–2.60	< 0.0001
	22 after exposure	2–nano	1.57#	1.37–1.80	< 0.0001
	2 days after exposure	2–micro	1.17	0.92–1.49	0.2070
	2 days after exposure	2–nano	0.99	0.82–1.19	0.8826
	3 days after exposure	2–micro	1.05	0.85–1.28	0.6552
	3 days after exposure	2–nano	0.92	0.76–1.13	0.4388
	Final examination		1.02	0.82–1.24	0.8376
Monocytes [1/nL]	Before exposure	0	1.00
	22 after exposure	2–micro	1.32	1.15–1.52	< 0.0001
	22 after exposure	2–nano	1.16	1.01–1.34	0.0337
	2 days after exposure	2–micro	1.04	0.85–1.27	0.7105
	2 days after exposure	2–nano	1.02	0.88–1.18	0.7842
	3 days after exposure	2–micro	0.97	0.81–1.17	0.7603
	3 days after exposure	2–nano	0.94	0.80–1.12	0.5013
	Final examination		1.13	0.99–1.28	0.0601
CRP [µg/mL]	Before exposure	0	1.00
	22 after exposure	2–micro	1.95	1.04–2.88	0.0348
	22 after exposure	2–nano	1.65	1.01–2.29	0.0479
	2 days after exposure	2–micro	2.45	1.07–3.81	0.0023
	2 days after exposure	2–nano	1.47	0.88–2.35	0.4111
	3 days after exposure	2–micro	1.52	0.89–2.41	0.3857
	3 days after exposure	2–nano	0.90	0.77–1.06	0.2532
	Final examination		1.23	0.64–2.17	0.5247
CC16 [ng/mL]	Before exposure	0	1.00
	22 after exposure	2–micro	1.12	1.00–1.25	0.0455
	22 after exposure	2–nano	1.07	0.97–1.19	0.1828
	2 days after exposure	2–micro	0.79	0.73–0.85	< 0.0001
	2 days after exposure	2–nano	0.82	0.74–0.90	< 0.0001
	3 days after exposure	2–micro	0.77	0.67–0.89	0.0003
	3 days after exposure	2–nano	0.82	0.72–0.93	0.0021
	Final examination		0.88	0.78–1.00	0.0524

^aOR adjusted for ZnO exposure, time of sampling, BMI, and total IgE. P values in bold are statistically significant

^#Statistically significant difference in effect size between micro- and nano-sized ZnO particles