Figure 1. Correlation between pharmacokinetic parameters of capecitabine metabolites and creatinine clearance (CLcr). A: The area under the plasma concentration–time curve (AUC)/dose of 5’-deoxy-5-fluorouridine (5’-DFUR) and CLcr were significantly inversely correlated (r=– 0.657, p=0.003). B: The maximum concentration (Cmax) ratio of 5’-DFUR/5’-deoxy-5-fluorocytidine (5’-DFCR) and CLcr were significantly inversely correlated (r=–0.554, p=0.017). C: The elimination half-life (t1/2) of 5’-DFUR and CLcr were not correlated (r=–0.003, p=0.990).