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. 2021 Jan 17;29(5):745–759. doi: 10.1038/s41431-020-00793-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Main milestones of the study with the timeline for the 22 Italian hospitals (P: Promoter, Policlinico Santa Maria Alle Scotte, Azienda Ospedaliera Universitaria Senese, Siena; 1: San Matteo Hospital Fondazione IRCCS, Pavia; 2:ASST Santi Paolo e Carlo, University of Milan, Italy; 3: Ospedale Maggiore di Crema, Italy; 4: ASST Valtellina e Alto Lario, Sondrio; 5: University Hospital of Modena and Reggio Emilia, Modena; 6: IRCCS, Lazzaro Spallanzani, Rome; 7: ASST-FBF-Sacco, Milan; 8: Santa Maria Hospital, Azienda Ospedaliera di Perugia, Perugia; 9: Treviso Hospital, Local Health Unit (ULSS) 2 Marca Trevigiana, Treviso; 10: Ospedale dell’Angelo, ULSS 3 Serenissima, Mestre; 11: Belluno Hospital, ULSS 1 Dolomiti, Belluno; 12: ASST Spedali Civili Hospital, Brescia; 13: Policlinico San Martino Hospital, IRCCS, Genova; 14: AORN dei Colli, Monaldi Hospital, Naples; 15: A.O.R.N. “Antonio Cardarelli”, Naples; 16: Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo; 17: IRCCS Istituto G. Gaslini, Genoa; 18: CEINGE Biotecnologie Avanzate, Naples; 19: San Donato Hospital, Arezzo; 20: Misericordia Hospital, Grosseto; 21: Fondazione Policlinico Universitario Agostino Gemelli IRCCS; 22: Luigi Curto Hospital, Polla (SA)). B Main milestones of the study with the timeline for local health units (Continuity Assistance Special Units, USCA) and departments of preventive medicine (1. USCA, Chianciano; 2: USCA Sansepolcro; 3: USCA Siena; 4: USCA Orbetello; 5: USCA Arezzo; 6: Department of preventive medicine Senese, Siena; 7: Department of preventive medicine Aretino-Casentino-Valtiberina, Arezzo; 8: Department of preventive medicine Alta Val d’Elsa, Poggibonsi; 9: Department of preventive medicine Amiata Senese e Val d’Orcia - Valdichiana Senese, Montepulciano). Other 11 USCA and 4 departments of preventive medicine have obtained IRB approval and they are going to start sample collection.