Table 3.
Significant differences in [11C]Ro15-4513 VS between individuals with MRI-negative TLE and healthy controls
| Cluster level |
Voxel level |
|||||||
|---|---|---|---|---|---|---|---|---|
| Volume (mm3) | P FWE-corr | Pseudo-T | x, y, z, mm | Region name | Proportion of SnPM analyses | |||
| TLE > controls | Pattern 1 (8/10 flips) | Cluster 1 | 83 492 ± 4 650 | 0.002 ± 0.001 | 5.21 ± 0.31 | 32 −17 −16 | Contralateral hippocampus | 8/8 |
| Secondary maxima: |
4.51 ± 0.26 | −32 −15 −16 | Ipsilateral hippocampus/temporal horn | 8/8 | ||||
| 4.56 ± 0.28 | 12 10 −02 | Contralateral caudate | 6/8 | |||||
| 4.29 ± 0.00 | −08 25 −02 | Corpus callosum near ipsilateral caudate | 2/8 | |||||
| Pattern 2 (2/10 flips) | Cluster 1 | 46 960 ± 3776 | 0.005 ± 0.001 | 5.00 ± 0.10 | 33 −18 −18 | Contralateral hippocampus | 2/2 | |
| Secondary maxima: |
4.27 ± 0.06 | 10 12 −02 | Contralateral caudate | 2/2 | ||||
| 4.38 | −06 28 −02 | Corpus callosum near ipsilateral caudate | 1/2 | |||||
| 4.02 | 04 26 −02 | Corpus callosum near contralateral caudate | 1/2 | |||||
| Cluster 2 | 36 840 ± 712 | 0.008 ± 0.001 | 4.77 ± 0.05 | −32 −16 −14 | Ipsilateral hippocampus/temporal horn | 2/2 | ||
| Secondary maxima: |
4.01 ± 0.19 | −39 03 −36 | Ipsilateral anterior medial temporal lobe | 2/2 | ||||
| 3.99 ± 0.12 | −60 −27 −16 | Ipsilateral inferior/middle temporal gyrus / posterior temporal lobe | 2/2 | |||||
| TLE < controls | – | – | – | – | – | – | – | – |
mm(3), (cubic) millimetres; pFWE-corr, P-value corrected for multiple comparisons via family-wise error correction. Pattern 1 refers to a single cluster extending to both ipsilateral and contralateral temporal lobes; Pattern 2 describes a very similar pattern where ipsilateral and contralateral clusters are not connected. See text for details.