FIGURE 1.

Spata4 overexpression increased body weight and subcutaneous fat mass in old mice. (a) Spata4 was overexpressed ubiquitously and representative Western blots show higher protein level in different organs and tissues of transgenic mice. (b) Body weight of Spata4 transgenic mice (TG) versus wild‐type (WT) mice. N = 15–20, *p < 0.05. (c) Representative images of male WT and TG at 6 and 24 months. The weight ratio of fat mass to body mass (d) and the ratio of subcutaneous fat to total fat mass (e) in Spata4 overexpressing mice and wild‐type mice. N = 9, **p < 0.01, ***p < 0.001