TABLE 2.
The top 10 predictive genes are shown for the top 1000 variable and top 1000 differential aging clocks presented in Figure 3. For each gene, its quantified importance in the random forest prediction model is provided
| Aging clock | Gene name | Protein name | Importance |
|---|---|---|---|
| 1000 Variable | KRT6C | Keratin, type II cytoskeletal 6C | 14.78989842 |
| 1000 Variable | KLK6 | Kallikrein‐6 | 14.13181626 |
| 1000 Variable | SPRR1B | Cornifin‐B | 12.23451207 |
| 1000 Variable | MMP10 | Stromelysin‐2 | 10.47366716 |
| 1000 Variable | CALML3 | Calmodulin‐like protein 3 | 9.350379696 |
| 1000 Variable | CEACAM5 | Carcinoembryonic antigen‐related cell adhesion molecule 5 | 8.906136426 |
| 1000 Variable | GRP | Gastrin‐releasing peptide | 8.344751464 |
| 1000 Variable | FGA | Fibrinogen alpha chain | 7.586499443 |
| 1000 Variable | KRT6B | Keratin, type II cytoskeletal 6B | 7.481560771 |
| 1000 Variable | PRSS2 | Trypsin‐2 | 7.316476098 |
| 1000 Differential | REG3A | Regenerating islet‐derived protein 3‐alpha | 40.34504236 |
| 1000 Differential | NR2E1 | Nuclear receptor subfamily 2 group E member 1 | 13.02751594 |
| 1000 Differential | DEFB119 | Beta‐defensin 119 | 12.62814497 |
| 1000 Differential | MIR10B | N/A | 11.9933185 |
| 1000 Differential | MIR100 | N/A | 10.6716294 |
| 1000 Differential | KRT6C | Keratin, type II cytoskeletal 6C | 10.30831422 |
| 1000 Differential | DPT | Dermatopontin | 10.11309756 |
| 1000 Differential | HLA‐F | HLA class I histocompatibility antigen, alpha chain F | 9.340543895 |
| 1000 Differential | KCNC2 | Potassium voltage‐gated channel subfamily C member 2 | 8.923200977 |
| 1000 Differential | INS | Insulin | 8.647671153 |