Table 1.
Different types of immunotherapy with their respective examples applied in various cancers
| Types of immunotherapy | Examples | |
|---|---|---|
| Cancer immunotherapy | Naked monoclonal antibodies | Alemtuzumab is used to treat some patients suffering from Chronic Lymphocytic leukemia |
| Conjugated antibodies | Brentuximab vedotin binds to CD30 antigen, used against Hodgkin’s lymphoma | |
| Bispecific monoclonal antibodies | Blinatumomab, whose one half binds to CD19 and the other half binds to CD3, used to treat acute lymphocytic leukemia | |
| Immune checkpoint inhibitors | Monoclonal antibody blockade of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) with ipilimumab | |
| Non-specific immunotherapy | Some interleukins and interferons are used | |
| • IFN-α for use against hairy cell leukemia; | ||
| • IL-2 is approved to treat advanced kidney cancer and metastatic melanoma | ||
| Targeted vaccine therapy | Sipuleucel-T (Provenge) is a dendritic cell vaccine, used to treat advanced prostate cancer | |
| • Tumor cell vaccine | ||
| • Antigen vaccine | ||
| • Peptide-based vaccine | ||
| • DNA-based vaccine | ||
| • Dendritic cell vaccine |