Fig. 2.

A, B Mean average error (MAE) for prediction accuracy is ~2.25 years (5-fold cross-validation in the Cam-CAN dataset). C Regions contributing most include the posterior inferior temporal gyrus (ITG), thalamus, primary cortex (including visual and motor cortices), prefrontal cortex, lateral occipital cortex, and insular cortex (z in mm). D Different brain region contributions in male and female groups, particularly in prefrontal regions and motor cortex (primary and premotor cortices) (green boxes; z in mm). E Regional contributions in age prediction (similar to D) in the three subgroups, Young (163 subjects aged 17–39 years), Middle (172 subjects aged 44–61 years), and Old (175 subjects aged 69–88 years), where the green arrows in each row highlight the difference of contributions in the same anatomical regions between the three groups. MAE, mean average error; BA, biological age; CA, chronological age; ICC, intraclass correlation coefficient; RMSE, root mean squared error; DoF, degrees of freedom.