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. 2020 Nov 3;46(1):53–69. doi: 10.1007/s13318-020-00650-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 5 — Predicted plasma exposures for a typical patient following administration of cariprazine 6 mg/day. Simulations involved: a single dose at 6 mg/day; b final dose at 6 mg/day under steady-state conditions; c uptitration to 6 mg/day by Day 4 as follows: 1.5 mg on Day 1, 3 mg on Day 2, 4.5 mg on Day 3, and 6 mg/day thereafter. AUC_0–24,ss area under the plasma concentration-time curve over a 24-h period at steady state. CAR cariprazine, DCAR desmethyl-cariprazine, DDCAR didesmethyl-cariprazine, Total CAR sum of CAR and major metabolites (DCAR and DDCAR)