Fig. 3.

Subsequent treatment after osimertinib. Overview of the pattern of progression and subsequent treatment after osimertinib. Treatment status of enrolled patients and sequential treatment following first-line osimertinib (A). Patterns of progression after osimertinib (B). The numbers in parentheses refer to the corresponding number of patients. Swimmer plot for sequential treatment after osimertinib (C). AE, adverse event; ALK, anaplastic lymphoma kinase; CTx, chemotherapy; EGFR, epidermal growth factor receptor; LN, lymph node; PD, progressive disease; Plt, platinum; TKI, tyrosine kinase inhibitor. ^a)Best supportive care (n=4), death (n=1), referral to another center (n=1), ^b)All patients had brain metastasis at baseline, ^c)Death due to drug-related interstitial pneumonia.