Table 2.
Sensitivity of activating EGFR mutation tests using circulating tumor DNA
| EGFR mutation | Tissue | Plasma ctDNA | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Mutyper | Cobas v2 | |||||
|
|
|
|||||
| Mutant | Wild-Type | Mutant | Wild-Type | Invalid | ||
| Mutant | 39 (100) | 24 (62) | 15 (39) | 25 (64) | 9 (23) | 5 (13) |
|
| ||||||
| Discordant with tissue | ||||||
|
| ||||||
| Case 1 | ex19del | ex19del/T790M | - | ex19del | - | - |
|
| ||||||
| Case 2 | G719X | G719A | - | ex19del | - | - |
|
| ||||||
| Sensitivity | 24/39 (62) | - | 25/39 (64) | - | - | |
|
| ||||||
| Sensitivity (Mutyper- or Cobas v2–positive) | 29/39 (74) | - | - | - | - | |
Values are presented as number (%). ctDNA, circulating tumor DNA; EGFR, epidermal growth factor receptor.