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Spatial distribution of LAG3- and TIM3-expressing T cell subsets. (A, B) The density of LAG3- and TIM3-expressing CD8+ T cells, FoxP3− CD4+ helper T cells, and FoxP3+ CD4+ regulatory T cells (Treg) in the tumor core, tumor margin, and stroma. *p < 0.05, **p < 0.01, ***p < 0.001; ns, not significant.
