Table 2.
Hematological parameters and univariate analysis for variables associated with pathologic complete response
| Characteristic | Total (n=306) | pCR (n=124) | Non-pCR (n=182) | Univariate | |
|---|---|---|---|---|---|
| Odds ratio (95% CI) | p-value | ||||
| Pre-CRT albumin (g/L) | 42.4 (40.4–44.8) | 42.8 (40.6–44.5) | 42.1 (40.2–45.0) | 0.993 (0.933–1.056) | 0.816 |
| Pre-CRT LDH (U/L) | 159.0 (140.0–181.1) | 153.4 (138.1–177.0) | 162.5 (141.5–184.1) | 1.003 (0.996–1.010) | 0.415 |
| Pre-CRT hemoglobin (g/L) | 138.5 (130.0–147.0) | 138.0 (128.2–147.7) | 139.0 (131.0–146.7) | 1.003 (0.988–1.017) | 0.723 |
| Pre-CRT WBC (×109/L) | 7.2 (6.1–9.0) | 7.2 (5.8–9.1) | 7.2 (6.3–8.9) | 1.021 (0.947–1.102) | 0.588 |
| Pre-CRT neutrophils (×109/L) | 4.4 (3.5–6.1) | 4.3 (3.4–6.1) | 4.6 (3.7–6.2) | 1.020 (0.938–1.110) | 0.636 |
| Pre-CRT monocytes (×109/L) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 1.181 (0.445–3.133) | 0.739 |
| Pre-CRT ALC (×109/L) | 1.9 (1.4–2.4) | 1.9 (1.4–2.5) | 1.9 (1.4–2.4) | 0.984 (0.702–1.379) | 0.924 |
| Pre-CRT platelets (×109/L) | 225 (187–271) | 216 (179–258) | 232 (190–286) | 1.002 (0.999–1.005) | 0.279 |
| Pre-CRT NLR | 2.5 (1.8–3.4) | 2.3 (1.7–3.2) | 2.6 (1.9–3.9) | 1.218 (1.050–1.414) | 0.009 |
| Pre-CRT PLR | 125.0 (90.6–164.6) | 114.7 (88.1–155.5) | 130.0 (93.1–171.3) | 1.005 (1.001–1.009) | 0.018 |
| Pre-CRT LMR | 3.9 (2.8–5.6) | 3.9 (3.0–5.6) | 3.9 (2.7–5.5) | 0.981 (0.945–1.019) | 0.325 |
| ALC nadir during CRT (×109/L) | 0.3 (0.2–0.5) | 0.4 (0.3–0.6) | 0.3 (0.2–0.5) | 0.193 (0.067–0.557) | 0.002 |
| Post-CRT albumin (g/L) | 42.0 (39.0–43.3) | 42.1 (39.5–43.5) | 41.9 (39.0–43.3) | 0.961 (0.886–1.042) | 0.332 |
| Post-CRT LDH (U/L) | 172.6 (159.1–201.0) | 174.7 (157.6–200.8) | 172.3 (160.0–202.8) | 1.002 (0.996–1.009) | 0.499 |
| Post-CRT hemoglobin (g/L) | 118.0 (109.0–128.0) | 118.0 (109.3–128.0) | 118.0 (109.0–126.0) | 0.997 (0.979–1.017) | 0.784 |
| Post-CRT WBC (×109/L) | 6.1 (4.8–6.8) | 6.0 (4.9–6.6) | 6.1 (4.8–6.9) | 1.040 (0.939–1.152) | 0.446 |
| Post-CRT neutrophils (×109/L) | 3.4 (2.6–4.4) | 3.5 (2.8–4.6) | 3.3 (2.5–4.3) | 0.972 (0.912–1.035) | 0.372 |
| Post-CRT monocytes (×109/L) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 1.491 (0.510–4.354) | 0.465 |
| Post-CRT ALC (×109/L) | 1.2 (0.9–1.6) | 1.2 (0.9–1.6) | 1.3 (0.9–1.7) | 1.242 (0.804–1.917) | 0.329 |
| Post-CRT platelets (×109/L) | 213 (176–262) | 202 (170–240) | 222 (178–270) | 1.004 (1.000–1.007) | 0.024 |
| Post-CRT NLR | 2.7 (1.9–3.7) | 2.8 (2.0–4.2) | 2.6 (1.8–3.6) | 0.991 (0.947–1.036) | 0.683 |
| Post-CRT PLR | 170.6 (127.8–243.9) | 164.1 (122.9–227.5) | 178.5 (133.3–249.3) | 1.003 (1.000–1.006) | 0.020 |
| Post-CRT LMR | 2.5 (1.8–3.5) | 2.6 (1.8–3.8) | 2.5 (1.8–3.4) | 0.967 (0.866–1.080) | 0.554 |
Values are presented as median (IQR). ALC, absolute lymphocyte count; CI, confidence interval; CRT, chemoradiotherapy; IQR, interquartile range; LDH, lactate dehydrogenase; LMR, lymphocyte to monocyte ratio; NLR, neutrophil to lymphocyte ratio; pCR, pathologic complete response; PLR, platelet to lymphocyte ratio; WBC, white blood cell.