Table 2.
Device Technologies Enabling SC Delivery of Large-Volume Biologics
| Technology (Manufacturer) | Key Features | References |
|---|---|---|
| SmartDose® 3.5 injector (West Pharma, Exton, PA, USA) | SC delivery of 3.5 mL at a customizable, pre-programmed delivery time Commercialized |
[67] |
| CRONO ambulatory infusion pumps (Canè Medical Technology, Rivoli TO, Italy) | Can be worn on elastic belt or collar strap for SC infusions of up to 100 mL Commercialized |
[61] |
| Infusion Pump (Sensile Medical, Olten, Switzerland) | SC delivery of 20 mL at flexible flowrates using an infusion pump worn on belt or in a belt-pouch Commercialized |
[62] |
| Libertas™ autoinjector (BD, Franklin Lakes, NJ, USA) | SC delivery of 2–5 mL and 5–10 mL with viscosities up to 50 cP | [66,68] |
| Lapas® patch pump (Bespak, King’s Lynn, UK) | Uses Bespak’s Vapoursoft® technology to deliver both viscous/non-viscous formulations over a range of different volumes and delivery times | [69] |
| enFuse® on-body platform (Enable Injections, Cincinnati, OH, USA) | SC delivery of up to 50 mL with a prefilled or user-filled syringe | [70] |
| Wearable injectors (Sonceboz, Sonceboz-Sombeval, Switzerland) | SC delivery of up to 20 mL of fluids up to 100 cP at programmable dosing rate | [71] |
| Wearable injection devices (Sorrel Medical, Netanya, Israel) | SC delivery of 3, 5, 10, 20, and 25 mL of high viscosity fluids | [72] |
| DrugDeliverySystems (Weibel, Zug, Switzerland) | SC delivery of 25 mL of high viscosity fluids | [73] |
| YpsoDose® (Ypsomed, Burgdorf, Switzerland) | SC delivery of 2–10 mL of fluids with a range of viscosities | [74] |
Abbreviation: OBDS, on-body delivery systems.