Table 2.
Univariate and multivariate Cox regression analyses of prognostic factors for survival in NSCLC patients with EGFR or HER2 Ex20ins
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Parameters | HR (95% CI) | P‐value | HR (95% CI) | P‐value |
| Gender | ||||
| Male | 1.00 | 1.00 | ||
| Female | 0.38 (0.13–1.09) | 0.073 | 0.22 (0.11–1.43) | 0.052 |
| Age, year | ||||
| <65 | 1.00 | |||
| ≥65 | 0.80 (0.26–2.45) | 0.702 | ||
| Smoking status | ||||
| Never | 1.00 | |||
| Ever/current | 1.73 (0.65–4.62) | 0.276 | ||
| Performance status | ||||
| 0–1 | 1.00 | |||
| 2 | 0.89 (0.31–2.59) | 0.835 | ||
| Family history | ||||
| Yes | 1.00 | |||
| No | 0.51 (0.18–1.39) | 0.188 | ||
| Disease stage | ||||
| IIIb | 1.00 | |||
| IV | 2.92 (0.27–3.99) | 0.350 | ||
| PD‐L1 expression | ||||
| <1% | 1.00 | 1.00 | ||
| ≥1% | 4.67 (1.80–12.1) | 0.002 | 6.21 (1.05–8.22) | 0.045 |
| CD4 expression | ||||
| No | 1.00 | |||
| Yes | 0.70 (0.25–1.98) | 0.506 | ||
| CD8 expression | ||||
| No | 1.00 | |||
| Yes | 0.46 (0.18–1.17) | 0.104 | ||
| TMB | ||||
| Low (<5 mutation/Mb) | 1.00 | 1.00 | ||
| High (≥5 mutation/Mb) | 6.7 (1.59–8.41) | 0.019 | 4.95 (1.46–6.84) | 0.025 |
CI, confidence interval; HR, hazard ratio; Mb, megabase; TMB, tumor mutational burden.