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. 2020 Dec;8(24):1674. doi: 10.21037/atm-20-6989

Figure 3.

Figure 3

Inhibition of Cx43 reduces podocyte apoptosis, injury, and ERS induced by HG or HG + microRNA-30 family inhibitors in vitro. Podocytes were distributed into five groups: control, HG, HG + Cx43 siRNA, HG + microRNA-30 family inhibitors, and HG + microRNA-30 family inhibitors + Cx43 siRNA. (A) Analyses of podocyte apoptosis among the five groups. (B) Western blot analyses of the protein expression of caspase12, Cx43, and podocin among the five groups. (C,D,E) The quantitative ratios are shown as the relative optical densities of the bands that are normalized to the expression of GAPDH. The data are representative of three similar experiments and quantified as the mean ± SEM. #, P<0.05 vs. the control group. *, P<0.05 vs. the HG group. ##, P<0.05 vs. HG + microRNA-30 family inhibitors. HG, high glucose; ERS, endoplasmic reticulum stress.