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. 2020 Dec;8(24):1643. doi: 10.21037/atm-20-7201

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Neferine inhibits tumorigenesis of xenograft tumors in vivo. (A) Tumor weight. (B) Tumor volume. (C,D) Apoptosis ratio was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining; representative images were magnified at 400×. (C,E,F) Ki67⁺ and survivin⁺ expression detected by immunohistochemical staining; representative images were magnified at 200×. (G,H) Superoxide dismutase level and 3,4-methylenedioxyamphetamine content were detected by enzyme-linked immunosorbent assay. Data are presented as mean ± standard deviation. *P<0.05, **P<0.01 vs. control.