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. 2020 Dec;8(24):1658. doi: 10.21037/atm-20-7424

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Differential expression genes (DEGs) and their gene enrichment analysis and protein-protein interaction (PPI) analysis. (A) DEGs between the QTRT1^high group and the QTRT1^low group were shown in the Volcano plot. The criteria of cut-off for DEGs significance was P<0.05 and absolute value of log2 fold change >0.5. The X-axis displays the log2 fold change for that gene relative to QTRT1 expression, while the Y-axis displays the −log10 P value for each gene. (B) Gene Ontology (GO) results for DEGs. The X-axis represents gene ratio and the Y-axis represents different enriched biological process terms. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) results for DEGs. The X-axis represents gene ratio and the Y-axis represents different enriched pathways. (D) PPI network of top 13 DEGs: 11 up-regulated genes and 2 down-regulated genes. The red circle indicates a positive correlation, and the green circle indicates a negative correlation.