Table 3. Multivariate analysis for DFS and OS of LUAD based on TCGA dataset.
| Variables | DFS | OS | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| QTRT1 (high vs. low) | 1.37 | 1.05–1.79 | 0.020 | 1.27 | 1.01–1.60 | 0.044 | |
| Age (≥60 vs. <60) | 1.14 | 0.87–1.49 | 0.349 | 1.03 | 0.81–1.32 | 0.801 | |
| Gender | 1.04 | 0.81–1.33 | 0.767 | 0.97 | 0.78–1.20 | 0.750 | |
| ALK | 0.93 | 0.73–1.19 | 0.572 | 0.92 | 0.74–1.14 | 0.439 | |
| EGFR | 1.32 | 1.02–1.71 | 0.034 | 1.18 | 0.95–1.48 | 0.135 | |
| KRAS | 1.37 | 1.06–1.78 | 0.016 | 1.38 | 1.10–1.73 | 0.006 | |
| LHX5 | 0.82 | 0.64–1.05 | 0.118 | 0.85 | 0.68–1.05 | 0.129 | |
| NRAS | 0.90 | 0.69–1.17 | 0.422 | 0.90 | 0.72–1.13 | 0.374 | |
| PIK3CA | 0.99 | 0.75–1.29 | 0.923 | 0.97 | 0.77–1.23 | 0.814 | |
| TP53 | 1.03 | 0.80–1.32 | 0.821 | 1.06 | 0.85–1.32 | 0.607 | |
DFS, disease-free survival; OS, overall survival; LUAD, lung adenocarcinoma; TCGA, The Cancer Genome Atlas; QTRT1, queuine tRNA-ribosyltransferase 1; HR, hazard ratio; CI, confidence interval; ALK: anaplastic lymphoma kinase; EGFR, epidermal growth factor receptor; KRAS, kirsten rat sarcoma viral oncogene; LHX5, LIM homeobox 5; NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; TP53, tumor protein p53.