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. 2020 Dec;8(24):1686. doi: 10.21037/atm-20-5272

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The life cycle of coronavirus in host cells; the virion lifecycle begins when the spike (S) protein binds to ACE2, the cellular receptor. Then the virus releases its plus sense genomic RNA into the host cell. The minus strand is then formed from the plus strand genomic RNA, from which subgenomic mRNAs are formed by transcription and then translated into relevant viral proteins. Genome RNA and viral protein are assembled and then released out of the cell. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; ER, endoplasmic recticulum; ACE2 receptor, angiotensin-converting enzyme 2 receptor.