. 2020 Dec;8(24):1641. doi: 10.21037/atm-20-6917

Table 1. Baseline characteristics of the included studies.

Study	Design	Ventilator mode		Sample size		Age (years)		Gender (M/F)		PaO₂/FiO₂ at baseline (mmHg)		APACHE II		Murray		Type of patients	APRV initial setting	Outcomes
Study	Design	EG	CG	EG	CG	EG	CG	EG	CG	EG	CG	EG	CG	EG	CG	Type of patients	APRV initial setting	Outcomes
Zhou et al.	RCT	APRV	LTV (VC)	71	67	51.5	52	50/21	41/26	121.7	138.3	22	20.2	–	–	ARDS P/F <250 mmHg	Ph = Pplat; PI =5 cmH₂O; TI >50% PEFR	1, 2, 3, 4, 5, 6, 7
Varpula et al.	RCT	APRV	LTV (SIMV + PC/PS)	30	28	50	44	21/9	18/10	150	164	15	14	3.0	3.1	ALI/ARDS P/F <200 mmHg	Ph =↓UIP; PI =↑LIP; Th =4 s; TI =1 s	1, 2, 6
Li et al.	RCT	APRV	LTV (VC)	16	16	43	46	–	–	180	179	28	27	3.3	2.9	ARDS P/F <300 mmHg	Ph <35 cmH₂O; Vt 6–8 mL/kg	1, 4, 5, 7
Putensen et al.	RCT	APRV	LTV (PCV)	15	15	40	42	11/4	13/2	243	238-	–	–	–	–	Trauma with ARDS	Ph =↓UIP; Vt <7 mL/kg; PI = LIP + 2 cmH₂O	1, 2, 3
Zhou et al.	RCT	APRV	LTV (SIMV + PS)	30	30	51	52	17/13	16/14	118.8	119.1	22.54	22.43	3.1	3.1	Moderate/severe ARDS	Ph =UIP; PI =LIP; Th =4 s; TI =1 s	1, 2, 3, 5, 6
Hirshberg et al.	RCT	APRV-LTV	LTV (VC)	18	17	57	51	9/9	8/9	98	131	27	32	–	–	ARDS P/F <200 mmHg	Ph = Pplat; PI =5 cmH₂O; Th =4–6 s; TI =50–70% PEFR	1, 2, 3, 5
Li et al.	RCT	APRV	LTV (SIMV + PS)	26	26	54	53	–	–	119	118	18.5	17.7	3.3	3.2	Moderate severe ARDS	Ph =30 cmH₂O; I =0; Th =4–8 s; TI =0.4–0.8 s	1, 2, 3, 4, 5, 6

Outcomes: 1, hospital mortality; 2, ventilator-free days on day 28; 3, length of ICU stay; 4, respiratory system compliance (day 3); 5, PaO₂/FiO₂ (day 3); 6, MAP (day 3); 7, pneumothorax. APRV, airway pressure release ventilation; LTVV, low tidal volume ventilation; RCT, randomized controlled trial; ARDS, acute respiratory distress syndrome; ICU, intensive care unit.