Figure 1.

Notch signalling pathway. Interaction of the ligands Dll4 and Jagged with the Notch-ECD activates the secretases ADAM and gamma-secretase cleaveage the two domains of Notch (ECD and ICD). Notch-ICD is released in the cytoplasm as an active form and translocates into the nucleus. In the nucleus Notch-ICD interacts with the CSL protein that in the absence of Notch-ID is inactivated by the a co-represor. Activated CSL forms a complex with proteins p300 and MAML1 that activates the transcription of Hes and Hey Notch related genes. ECD, extracellular domain. ICD, intracellular domain.